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Single-cell multi-omics analysis of human testicular germ cell tumor reveals its molecular features and microenvironment
Nature
Seminoma is the most common malignant solid tumor in 14 to 44 year-old men. However, its molecular features and tumor microenvironment (TME)...
5 個月前
A molecular programme for the specification of germ cell fate in mice
Nature
Germ cell fate in mice is induced in proximal epiblast cells by the extra-embryonic ectoderm, and is not acquired through the inheritance of...
262 個月前
Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence
Nature
Germ cell tumors (GCTs) are neoplasms of the testis, ovary and extragonadal sites that occur in infants, children, adolescents and adults.
13 個月前
Blimp1 is a critical determinant of the germ cell lineage in mice
Nature
Germ cell fate in mice is induced in pluripotent epiblast cells in response to signals from extraembryonic tissues. The specification of...
228 個月前
Characterizing the mutational burden, DNA methylation landscape, and proteome of germ cell tumor-related somatic ...
Nature
Germ cell tumors (GCT) might undergo transformation into a somatic-type malignancy (STM), resulting in a cell fate switch to tumors usually...
8 個月前
Identification of four new susceptibility loci for testicular germ cell tumour
Nature
Genome-wide association studies (GWAS) have identified multiple risk loci for testicular germ cell tumour (TGCT), revealing a polygenic...
103 個月前
A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
Nature
PRDM14 is a crucial regulator of mouse primordial germ cells (mPGCs), epigenetic reprogramming and pluripotency, but its role in the...
51 個月前
The neonatal southern white rhinoceros ovary contains oogonia in germ cell nests | Communications Biology
Nature
The northern white rhinoceros is functionally extinct with only two females left. Establishing methods to culture ovarian tissues,...
7 個月前
Derivation of human primordial germ cell-like cells in an embryonic-like culture
Nature
Primordial germ cells (PGCs) are the embryonic precursors of sperm and eggs. They transmit genetic and epigenetic information across...
5 個月前
Comparative Genomic and In Situ Hybridization of Germ Cell Tumors of the Infantile Testis | Laboratory Investigation
Nature
Chromosomal information on germ cell tumors of the infantile testis, ie, teratomas and yolk sac tumors, is limited and controversial.
287 個月前